IMMUNOHISTOCHEMICAL CHARACTERISTICS IN VARIOUS ESOPHAGEAL ANOMALIES

Abstract

In the study of various clinical and morphological forms of esophageal atresia—one of the developmental anomalies of the esophagus—immunohistochemical analysis plays a pivotal role. The chromogranin marker is used to identify neuroendocrine cells, specifically secretory neurons that indicate neuromuscular synapses, as well as to detect the ongoing synthesis of functional peptide bonds. Being a glycoprotein by nature, this marker allows for the assessment of the morpho-functional state of vesicles within the muscle layer by staining the components of neuromuscular synapses. Such analysis provides an essential foundation for planning appropriate treatment strategies based on the variant of esophageal atresia present.