ASSESSMENT OF THE DYNAMICS OF THE INFLAMMATORY CYTOKINES IN DEVELOPING OF ANEMIA WITH DIFFERENT ETIOLOGY IN CHRONIC HEART FAILURE

Abstract

According to the results of studies in recent years, in patients with chronic heart failure (CHF) occurs a number of neurohumoral reactions, including the activation of inflammatory cytokines (α - tumor necrosis factor, interleukin-1 and interleukin-6), are associated with anemia of chronic diseases (1,2). It is known that currently, in the development of anemia in CHF, it is important to identify hepcidin, which controls iron homeostasis, and the mechanisms of its interaction with inflammatory mediators as well as to develop effective treatment methods aimed at reducing the activity of pathogenetic factors (3,4,5,6,).