tijst

FEATURES OF HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE AND THYROTOXICOSIS

Authors

  • Yarmatov Suvon Tatlibayevich

    Assistant of the Department of Propaedeutics of Internal Diseases, Samarkand State Medical University
    Author

  • Jurayev Javohir

    Samarkand State Medical University Faculty of treatment student group 511
    Author

  • Meyliyev Lazizbek

    Samarkand State Medical University Faculty of treatment student group 511 Samarkand State Medical University, Samarkand, Uzbekistan
    Author

  • Muzaffarova Malika Sho’hratovna

    Assistant at the ABU ALI IBN SINO SIAB COLLEGE OF PUBLIC HEALTH (Samarkand)
    Author

Keywords:

chronic heart failure, coronary heart disease, thyrotoxicosis, vegetative imbalance, threshold level NT-proBNP, left ventricular remodeling.

Abstract

Goal. To evaluate the diagnostic significance of criteria for chronic heart failure (CHF) and to study the features of structural and functional remodeling of the left heart in patients with coronary heart disease (CHD) and thyrotoxicosis.

Material and methods. 131 patients aged 45-65 years with coronary heart disease were examined, CHF and/or thyrotoxicosis. The clinical condition of patients and exercise tolerance were assessed, and the level of N-terminal stress was determined. A fragment of the precursor of the cerebral natriuretic peptide (NTproBNP), Holter electrocardiogram monitoring and echocardiographic examination (EchoCG) with Dopplerography were performed.

Results. Cardiac arrhythmias were detected more often in patients with coronary heart disease, CHF and thyrotoxicosis than in patients with coronary heart disease and CHF without thyrotoxicosis (atrial fibrillation, sinus tachycardia, supraventricular extrasystole), a more pronounced autonomic imbalance with a predominance of activity of the sympathetic link of the autonomic nervous system. Elevated levels of NT-proBNP (>125 pg/ml) were detected in both patients with CHF and patients with thyrotoxicosis, regardless of the presence of cardiovascular

diseases. Concentration of NT-proBNP in patients with coronary heart disease and thyrotoxicosis without CHF exceeded the threshold value by 2.8 times (p=0.001). The highest level of NT-proBNP in patients with coronary heart disease, CHF and thyrotoxicosis is due to The effect on its secretion is not only remodeling of the left ventricle (LV), but also hyperfunction of the thyroid gland. A higher threshold

value of NT-proBNP was determined (according to the results of this study — 556.4 pg/ml) for the diagnosis of CHF with preserved and intermediate LV ejection fraction (LVEF) in patients with coronary heart disease and thyrotoxicosis. The analysis of echocardiography parameters in patients with coronary heart disease, CHF and thyrotoxicosis revealed significantly lower values of linear and volumetric LV indices, LV type I diastolic dysfunction in 100% of cases, an intermediate type of LV ejection fraction (48%), more the frequent occurrence of concentric LV hypertrophy (84% of cases).

References

1. Ярмухамедова, С. Х., & Амирова, Ш. А. (2023). Определение показателей диастолической дисфункции правого желудочка у больных с АГ. Science and Education, 4(5), 595-600.

2. Ярмухаммедова, С., Гаффоров, Х., & Ярматов, С. (2020). ЗНАЧЕНИЕ СИСТОЛИЧЕСКОЙ И ДИАСТОЛИЧЕСКОЙ ДИСФУНКЦИИ СЕРДЦА ПРИ ЦИРРОЗЕ ПЕЧЕНИ. Журнал кардиореспираторных исследований, 1(2), 85-87.

3. Yarmuxamedova, S. X., & Normatov, M. B. R. (2021). SURUNKALI GLOMERULONEFRIT BILAN KASALLANGAN BEMORLARDA SUTKALIK QON BOSIMINING XARAKTERISTIKASI. Scientific progress, 2(2), 706-710.

4. Yarmuxamedova, S. X., & Normatov, M. B. R. (2021). SURUNKALI GLOMERULONEFRIT BILAN OG'RIGAN BEMORLARDA MARKAZIY GEMODINAMIKA KO'RSATKICHLARINI BAHOLASH. Scientific progress, 2(2), 696-699.

5. Nazarov, F. Y., & Yarmuxamedova, S. X. (2023). Shifoxonadan tashqari pnevmoniyaning kattalarga uchraydigan klinik xususiyati. Science and Education, 4(5), 608-616.

6. Xabibovna, Y. S., Xudoyberdiyevich, G. X., & Totliboyevich, Y. S. (2020). Jigar Sirrozida Yurakning Sistolik Va Diastolik Disfunktsiyasining Ahamiyati. Journal of cardiorespiratory research, 1(2), 85-87.

7. Ярмухамедова, С. Х., & Афмирова, Ш. А. (2022). Изменения диастолической функции правого желудочка при гипертонической болезни. Science and Education, 3(11), 270-280.

8. Habibovna, Y. S., & Bo’Riboyevich, N. M. (2020). Surunkali Glomerulonefrit Bilan Og ‘Rigan Bemorlarda Arterial Qon Bosimining Sutkalik Monitoring Ko ‘Rsatkichlarini Baxolash. Journal of cardiorespiratory research, 1(1), 103-108.

9. Khabibovna, Y. S. (2020). Оценка Признаков Диастолической Дисфункции Правого Желудочка У Больных С Артериальной Гипертонией. Journal of cardiorespiratory research, 1(2), 88-92.

10. Khabibovna, Y. S., & Buribaevich, N. M. (2020). Study Of Parameters Of Central Hemodynamics In Patients With Chronic Glomerulonephritis. Достижения науки и образования, (13 (67)), 57-59.

11. Khusainova, M. A., & Yarmatov, S. T. (2021). CARDIAC ARRHYTHMIAS AND CARDIOHEMODYNAMIC DISORDERS IN PATIENTS VIRAL CIRRHOSIS OF THE LIVER. Scientific progress, 2(2), 196-202.

12. Yarmatov, S. T., & Xusainova, M. A. (2021). Yurak Ishemik Kasalligi Mavjud Bo’lgan Bemorlarda. Scientific progress, 2(3), 785-791.

13. Yarmatov, S. T. (2021). Yurak Ishemik Kasalligi Va Bachadon Miomasi Bo'lgan Bemorlarni Davolashda Antikougulyant Va Antitrombositar Terapiyani O’tkazish Bo’yicha Klinik Kuzatuvni Olib Borish. Scientific progress, 2(3), 792-797.

14. Yarmatov, S. T., & Xusainova, M. A. (2021). BRONXIAL ASTMA MAVJUD BO’LGAN BEMORLARDA GASTROEZOFAGIAL REFLYUKS KASALLIGI DIAGNOSTIKASI VA OLIB BORISH ALGORITMI. Scientific progress, 2(2), 208-213.

15. Yarmatov, S. T., & Yarmahammadov, U. K. (2022). Semizlik–Zamonaviy Tibbiyotda Dolzarb Muammo Sifatida Qolmoqda. Scientific progress, 3(4), 1196-1203.

16. Khusainova, M. A. (2023). Cystatin C is an early marker of decreased kidney function. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 485-490.

17. Khusainova, M. A., Eshmamatova, F. B., Ismoilova, K. T., & Mamadiyorova, M. M. (2023). METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS AS A CRITERION OF CARDIOVASCULAR RISK. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 331-339.

18. Khusainova, M. A. (2023). Comorbidity thyrotoxicosis with coronary heart disease. Science and Education, 4(5), 205-213.

19. Khusainova, M. A., Bekmuradova, M. S., Makhmudova, K. D., & Uzokov, J. B. (2023). Echocardiographic changes of the left ventricle in bronchial asthma. Science and Education, 4(5), 214-221.

20. Khusainova, M. A., Toirov, D. R., Khaydarov, S. N., & Kamolova, D. D. (2023). MORPHOFUNCTIONAL PARAMETERS OF THE HEART IN WOMEN SUFFERING FROM ESSENTIAL ARTERIAL HYPERTENSION IN POSTMENOPAUSE AND ON THE BACKGROUND OF TREATMENT. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 322-330.

21. Khusainova, M. A., Khaydarov, S. N., Makhmudova, K. D., & Nayimov, A. S. (2023). Prevalence of bronchiolitis in patients with Rheumatoid arthritis. Science and Education, 4(5), 232-241.

22. Ibragimov, K., Sultonov, I., & Ravshanova, M. (2024). The Effectiveness of the Combination Therapy with biologic DMARDS in Rheumatoid Arthritis. Frontiers of Global Science, 2(1), 17-24.

23. Ziyadullaev, S. K., Sultonov, I. I., Dushanova, G. A., & Akbarovna, K. S. (2021). The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science, 12(3), 2908-2916.

24. Sobirov, A., & Sultonov, I. (2024). COMPREHENSIVE ANALYSIS OF CLINICAL NEUROPSYCHOLOGICAL AND NEUROIMAGING ASPECTS OF ALZHEIMER'S DISEASE. Frontiers of Global Science, 2(1), 25-29.

25. Islomovich, S. I. (2024). FEATURES OF THE COURSE OF PREGNANCY IN RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 77-84.

26. Islomovich, S. I. (2024). Gender characteristics of the current rheumatoid arthritis. International journal of medical sciences, 4(10), 3-8.

27. Хамраева, Н. А., Султонов, И. И., & Хасанов, Ф. Ш. У. (2019). Кожные проявления у больных системной красной волчанкой. Вопросы науки и образования, (28 (77)), 128-131.

28. Sultonov, I. I., Kh, Z. S., Ruzybakieva, M. R., Kireev, V. V., Aripova, T. U., & Suyarov, A. A. (2021). Pharmacogenetic Aspects of Drug Resistance in Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 25(3), 4147-4150.

29. Kireev, V. V., Sultonov, I. I., Ziyadulaaev, S. K., Suyarov, A. A., Aripova, T. U., Usmanbekova, K. T., & Nasretdinova, M. T. (2021). Genetic Engineered Preparations-An Innovative Approach in the Treatment of Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 25(3), 4114-4119.

30. Hamraeva, N. A., Sultonov, I. I., & Hasanov, F. S. (2020). Systemic lupus erythematosus treatment strategy. Journal of Critical Reviews, 7(9), 269-270.

31. Тоиров, А. Э., Султонов, И. И., & Тоиров, Э. С. (2020). ЗНАЧЕНИЕ ДИСФУНКЦИИ ПОЧЕК У БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ МИОКАРДА НА ФОНЕ САХАРНОГО ДИАБЕТА 2-ГО ТИПА. Вестник науки и образования, (9-3 (87)), 86-91.

32. Иргашева, У. З., Султонов, И. И., & Тоиров, Д. Р. (2013). Признаки дебюта системной красной волчанки. Академический журнал Западной Сибири, 9(1), 15-15.

33. Нурматова, Л., Султонов, И., & Тоиров, Э. (2011). Эффективность препаратов пищеварительной активности в комплексном лечении больных хроническим гепатитом. Журнал проблемы биологии и медицины, (3 (66)), 107-110.

34. Sultonov, I. I., Xasanov, F. S., Eshmuratov, S., Uralov, R. S., Shukurova, D., & Ziyadullayev, S. X. Predictors of Systemic Lupus Erythematosus: A Case-control Study. International journal of health sciences, 6(S10), 175-182.

35. Ismailova, A. A., Uralova, S. A., Nigmatova, L. M., Adylov, D. G., Petrova, T. A., Nabieva, U. P., & Avazova, T. A. (2017). The optimization of technique of detection of cryoglobulins in conditions of clinical diagnostic laboratory. Klinicheskaia Laboratornaia Diagnostika, 62(1), 50-52.

36. Avazova, T., Khaitova, N., & Ismailova, A. (2013). Significance of IL-6 and IL-17 cytokines in diagnostics and prognosis of the metabolic syndrome. Medical and Health Science Journal, 14(1), 40-45.

37. Авазова, T. (2012). Метаболический синдром (обзор литературы). Журнал вестник врача, 1(3), 217-219.

38. Авазова, Т. А., & Хаитова, Н. М. (2011). ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ ПРЕПАРАТА" TAF" ЛАКТОФЛОР У БОЛЬНЫХ МЕТАБОЛИЧЕСКИМ СИНДРОМОМ. Врач-аспирант, 49(6.1), 209-212.

39. Avazova, T., & Rogelio, P. (2024). Effects of Ursodeoxycholic Acid on Inflammatory Markers IL-6 and IL-17 in Patients with Metabolic Syndrome. Frontiers of Global Science, 2(1), 12-16.

40. Khusinov, A., Islamova, K., & Ziyadullaev, S. (2024). GASTROINTESTINAL TRACT DAMAGE IN PATIENTS WITH CORONAVIRUS INFECTION. Medicine, pedagogy and technology: theory and practice, 2(5), 141-147.

41. Исламова, К. А., & Тоиров, Э. С. (2019). Значение факторов риска на качество жизни больных остеоартрозом. In Актуальные вопросы современной медицинской науки и здравоохранения: сборник статей IV Международной научно-практической конференции молодых учёных и студентов, IV Всероссийского форума медицинских и фармацевтических вузов «За качественное образование»,(Екатеринбург, 10-12 апреля 2019): в 3-х т.-Екатеринбург: УГМУ, CD-ROM.. Федеральное государственное бюджетное образовательное учреждение высшего образования «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации.

42. Akramovna, I. K., & Xudoyberdiyevna, K. G. (2020). QANDLI DIABET KASALLIGI FONIDA YURAK QON TOMIR TIZIMI KASALLIKLARINING KLINIK KECHUV XUSUSIYATLARI. Journal of cardiorespiratory research, 1(3), 59-62.

43. Islamova, K. A., Olimdjanova, F. J. Q., Ziyadullaev, S. K., & Kamalov, Z. S. (2022). RISK FACTORS FOR EARLY DEVELOPMENT OF OSTEOARTHROSIS.

44. Mamasoliyevna, D. N., Akmalovna, K. N., & Alisherovna, K. M. (2022). Quality of Life Depending on Gender. The Peerian Journal, 11, 71-77.

45. Хусаинова, М. А. (2021). ХРОНИЧЕСКАЯ СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬ У БОЛЬНЫХ РАННИМ РЕВМАТОИДНЫМ АРТРИТОМ. Journal of cardiorespiratory research, 2(4), 67-69.

46. Khusainova, M. A., & Yarmatov, S. T. (2021). CARDIAC ARRHYTHMIAS AND CARDIOHEMODYNAMIC DISORDERS IN PATIENTS VIRAL CIRRHOSIS OF THE LIVER. Scientific progress, 2(2), 196-202.

47. Khaydarov, S. N., Khusainova, M. A., Uzokov, J. B., & Makhmudova, K. D. (2023). Heart failure and the risk of hypoglycemia. Science and Education, 4(5), 222-231.

48. Khusainova, M. A., Gafforov, X. X., Eshmamatova, F. B., & Khayitov, S. M. (2023). Assessment of the quality of life in patients with exogenous allergic alveolitis. Science and Education, 4(2), 145-152.

49. Khusainova, M. A., Gafforov, K. K., Uzokov, J. B., & Tairova, Z. K. (2023). THE CHANGE IN THE QT INTERVAL IS A MARKER OF THE SEVERITY OF LIVER CIRRHOSIS. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 94-101.

Downloads

Published

2025-07-29

Issue

Vol. 1 No. 3 (2025): CONFERENCE OF ADVANCE SCIENCE & EMERGING TECHNOLOGIES

Section

Articles