MORPHOLOGICAL AND HISTOGENETIC REMODELING OF THE SPLEEN IN POSTNATAL OFFSPRING BORN TO MOTHERS SUBJECTED TO CHRONIC EXPERIMENTAL STRESS

Abstract

Maternal exposure to chronic stress during pregnancy and lactation represents a critical epigenetic and neuroendocrine factor capable of altering fetal and postnatal organogenesis. Among immune organs, the spleen demonstrates high sensitivity to glucocorticoid-mediated stress responses due to its complex vascular architecture and lymphoid composition.